Rex C. Haydon, MD PhD

Rex Haydon, MD, PhD, focuses on the comprehensive treatment of malignant and benign tumors in bone or soft tissue. He specializes in the surgical care of bone and soft tissue tumors, including limb-salvage and reconstructive surgery of the upper and lower extremities. Dr. Haydon works with an integrated team of specialists to ensure that patients have access to the most innovative and effective treatment options available.



Also a skilled physician scientist, his research focuses on advancing the treatment of musculoskeletal tumors. Dr. Haydon has a particular interest in the underlying causes of musculoskeletal neoplasms. Author of more than 25 articles and book chapters, he has accepted career development awards from both the Orthopaedic Research and Education Foundation and the National Institutes of Health. Additionally, Dr. Haydon's research has been supported by the Musculoskeletal Tumor Foundation.

The University of Chicago
Chicago, Illinois
Orthopaedic Fellowship - Oncology
2003

The University of Chicago
Chicago, Illinois
Orthopaedic Fellowship - Research
2002

The University of Chicago
Chicago, Illinois
Resident - Orthopaedic Surgery
2001

The University of Chicago
Chicago, Illinois
Ph.D - Anthropology
1996

The University of Chicago
Chicago, Illinois
M.A. - MAPSS (Social Sciences),
1993

The University of Chicago
Chicago, Illinois
B.A. - Anthropology
1988

Integrative analysis of immune-related multi-omics profiles identifies distinct prognosis and tumor microenvironment patterns in osteosarcoma.
Shi D, Mu S, Pu F, Liu J, Zhong B, Hu B, Ni N, Wang H, Luu HH, Haydon RC, Shen L, Zhang Z, He TC, Shao Z. Integrative analysis of immune-related multi-omics profiles identifies distinct prognosis and tumor microenvironment patterns in osteosarcoma. Mol Oncol. 2021 Dec 11.
PMID: 34894177

OUHP: an optimized universal hairpin primer system for cost-effective and high-throughput RT-qPCR-based quantification of microRNA (miRNA) expression.
He F, Ni N, Wang H, Zeng Z, Zhao P, Shi D, Xia Y, Chen C, Hu DA, Qin KH, Wagstaff W, Qin D, Hendren-Santiago B, Ho SH, Haydon RC, Luu HH, Reid RR, Shen L, Gan H, Fan J, He TC. OUHP: an optimized universal hairpin primer system for cost-effective and high-throughput RT-qPCR-based quantification of microRNA (miRNA) expression. Nucleic Acids Res. 2021 Nov 25.
PMID: 34850128

A one-step construction of adenovirus (OSCA) system using the Gibson DNA Assembly technology.
Ni N, Deng F, He F, Wang H, Shi D, Liao J, Zou Y, Wang H, Zhao P, Hu X, Chen C, Hu DA, Sabharwal M, Qin KH, Wagstaff W, Qin D, Hendren-Santiago B, Haydon RC, Luu HH, Reid RR, Shen L, He TC, Fan J. A one-step construction of adenovirus (OSCA) system using the Gibson DNA Assembly technology. Mol Ther Oncolytics. 2021 Dec 17; 23:602-611.
PMID: 34977337

Correction: Adenovirus-Mediated Efficient Gene Transfer into Cultured Three-Dimensional Organoids.
Wang N, Zhang H, Zhang BQ, Liu W, Zhang Z, Qiao M, Zhang H, Deng F, Wu N, Chen X, Wen S, Zhang J, Liao Z, Zhang Q, Yan Z, Yin L, Ye J, Deng Y, Luu HH, Haydon RC, Liang H, He TC. Correction: Adenovirus-Mediated Efficient Gene Transfer into Cultured Three-Dimensional Organoids. PLoS One. 2021; 16(10):e0259544.
PMID: 34710199

Primary Desmoplastic Small Round Cell Tumor of the Femur: Case Report and Review of a Rare Intraosseous Malignancy.
Sharma AE, deVries JA, Agrawal C, Haydon RC, Krausz T, Pytel P, Cipriani NA. Primary Desmoplastic Small Round Cell Tumor of the Femur: Case Report and Review of a Rare Intraosseous Malignancy. Int J Surg Pathol. 2021 Oct 16; 10668969211046017.
PMID: 34657504

Reversibly immortalized keratinocytes (iKera) facilitate re-epithelization and skin wound healing: Potential applications in cell-based skin tissue engineering.
Zhong J, Wang H, Yang K, Wang H, Duan C, Ni N, An L, Luo Y, Zhao P, Gou Y, Sheng S, Shi D, Chen C, Wagstaff W, Hendren-Santiago B, Haydon RC, Luu HH, Reid RR, Ho SH, Ameer GA, Shen L, He TC, Fan J. Reversibly immortalized keratinocytes (iKera) facilitate re-epithelization and skin wound healing: Potential applications in cell-based skin tissue engineering. Bioact Mater. 2022 Mar; 9:523-540.
PMID: 34820586

Antiparasitic mebendazole (MBZ) effectively overcomes cisplatin resistance in human ovarian cancer cells by inhibiting multiple cancer-associated signaling pathways.
Huang L, Zhao L, Zhang J, He F, Wang H, Liu Q, Shi D, Ni N, Wagstaff W, Chen C, Reid RR, Haydon RC, Luu HH, Shen L, He TC, Tang L. Antiparasitic mebendazole (MBZ) effectively overcomes cisplatin resistance in human ovarian cancer cells by inhibiting multiple cancer-associated signaling pathways. Aging (Albany NY). 2021 07 07; 13(13):17407-17427.
PMID: 34232919

Argonaute (AGO) proteins play an essential role in mediating BMP9-induced osteogenic signaling in mesenchymal stem cells (MSCs).
Mao Y, Ni N, Huang L, Fan J, Wang H, He F, Liu Q, Shi D, Fu K, Pakvasa M, Wagstaff W, Tucker AB, Chen C, Reid RR, Haydon RC, Ho SH, Lee MJ, He TC, Yang J, Shen L, Cai L, Luu HH. Argonaute (AGO) proteins play an essential role in mediating BMP9-induced osteogenic signaling in mesenchymal stem cells (MSCs). Genes Dis. 2021 Nov; 8(6):918-930.
PMID: 34522718

BMP9-initiated osteogenic/odontogenic differentiation of mouse tooth germ mesenchymal cells (TGMCS) requires Wnt/ß-catenin signalling activity.
Luo W, Zhang L, Huang B, Zhang H, Zhang Y, Zhang F, Liang P, Chen Q, Cheng Q, Tan D, Tan Y, Song J, Zhao T, Haydon RC, Reid RR, Luu HH, Lee MJ, El Dafrawy M, Ji P, He TC, Gou L. BMP9-initiated osteogenic/odontogenic differentiation of mouse tooth germ mesenchymal cells (TGMCS) requires Wnt/ß-catenin signalling activity. J Cell Mol Med. 2021 03; 25(5):2666-2678.
PMID: 33605035

Modeling colorectal tumorigenesis using the organoids derived from conditionally immortalized mouse intestinal crypt cells (ciMICs).
Wu X, Li Z, Zhang H, He F, Qiao M, Luo H, Zhang J, Zhang M, Mao Y, Wagstaff W, Zhang Y, Niu C, Zhao X, Wang H, Huang L, Shi D, Liu Q, Ni N, Fu K, Haydon RC, Reid RR, Luu HH, He TC, Wang Z, Liang H, Zhang BQ, Wang N. Modeling colorectal tumorigenesis using the organoids derived from conditionally immortalized mouse intestinal crypt cells (ciMICs). Genes Dis. 2021 Nov; 8(6):814-826.
PMID: 34522710

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Orlov Visiting Professor in Orthopaedic Oncology
Loyola University of Chicago
2018

Senior Faculty Scholar
Bucksbaum Institute for Clinical Excellence
2017

Gerald S. Laros Resident Teaching Award
2011

Keynote Speaker
Pritzker School of Medicine White Coat Ceremony
2010

American-British-Canadian Traveling Fellowship, AOA
2009

Induction into ??? (Beta Chapter) as Faculty member by Pritzker School of Medicine
2008

Gerald S. Laros Resident Teaching Award
2007

Orthopaedic Research Society Career Development Award
2006

Kappa Delta Ann Doner Vaughan Award, Co-Recipient, AAOS/ORS
2006

Marshall R. Urist Young Investigator Award, Association of Bone & Joint Surgeons
2006

John J. Fahey, MD Memorial North American Traveling Fellowship, AOA
2005

K08 Mentored Clinical Scientist Development Award, NIH-NIAMS
2004 - 2009

Thomas M. Coffman OREF Career Development Award
2003 - 2005

Best Poster Award: Charles Huggins Conference: “Upregulation Of cKit In Giant Cell Tumor of Bone: Po
2002

Howard Schneider Award for Best Manuscript at the OREF Midwest Conference
2000