Rex C. Haydon, MD

Rex Haydon, MD, PhD, focuses on the comprehensive treatment of malignant and benign tumors in bone or soft tissue. He specializes in the surgical care of bone and soft tissue tumors, including limb-salvage and reconstructive surgery of the upper and lower extremities. Dr. Haydon works with an integrated team of specialists to ensure that patients have access to the most innovative and effective treatment options available.



Also a skilled physician scientist, his research focuses on advancing the treatment of musculoskeletal tumors. Dr. Haydon has a particular interest in the underlying causes of musculoskeletal neoplasms. Author of more than 25 articles and book chapters, he has accepted career development awards from both the Orthopaedic Research and Education Foundation and the National Institutes of Health. Additionally, Dr. Haydon's research has been supported by the Musculoskeletal Tumor Foundation.

The University of Chicago
Chicago, Illinois
Orthopaedic Fellowship - Oncology
2003

The University of Chicago
Chicago, Illinois
Orthopaedic Fellowship - Research
2002

The University of Chicago
Chicago, Illinois
Resident - Orthopaedic Surgery
2001

The University of Chicago
Chicago, Illinois
Ph.D - Anthropology
1996

The University of Chicago
Chicago, Illinois
M.A. - MAPSS (Social Sciences),
1993

The University of Chicago
Chicago, Illinois
B.A. - Anthropology
1988

Blockade of IGF/IGF-1R signaling axis with soluble IGF-1R mutants suppresses the cell proliferation and tumor growth of human osteosarcoma.
Cao D, Lei Y, Ye Z, Zhao L, Wang H, Zhang J, He F, Huang L, Shi D, Liu Q, Ni N, Pakvasa M, Wagstaff W, Zhao X, Fu K, Tucker AB, Chen C, Reid RR, Haydon RC, Luu HH, He TC, Liao Z. Blockade of IGF/IGF-1R signaling axis with soluble IGF-1R mutants suppresses the cell proliferation and tumor growth of human osteosarcoma. Am J Cancer Res. 2020; 10(10):3248-3266.
PMID: 33163268

A reverse transcriptase-mediated ribosomal RNA depletion (RTR2D) strategy for the cost-effective construction of RNA sequencing libraries.
Zeng Z, Huang B, Wang X, Fan J, Zhang B, Yang L, Feng Y, Wu X, Luo H, Zhang J, Zhang M, He F, Mao Y, Pakvasa M, Wagstaff W, Li AJ, Liu B, Ding H, Zhang Y, Niu C, Wu M, Zhao X, Wolf JM, Lee MJ, Huang A, Luu HH, Haydon RC, He TC. A reverse transcriptase-mediated ribosomal RNA depletion (RTR2D) strategy for the cost-effective construction of RNA sequencing libraries. J Adv Res. 2020 Jul; 24:239-250.
PMID: 32373357

lncRNA Rmst acts as an important mediator of BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs) by antagonizing Notch-targeting microRNAs.
Zhang Z, Liu J, Zeng Z, Fan J, Huang S, Zhang L, Zhang B, Wang X, Feng Y, Ye Z, Zhao L, Cao D, Yang L, Pakvasa M, Liu B, Wagstaff W, Wu X, Luo H, Zhang J, Zhang M, He F, Mao Y, Ding H, Zhang Y, Niu C, Haydon RC, Luu HH, Lee MJ, Wolf JM, Shao Z, He TC. lncRNA Rmst acts as an important mediator of BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs) by antagonizing Notch-targeting microRNAs. Aging (Albany NY). 2019 12 11; 11(24):12476-12496.
PMID: 31825894

Stem cell therapy for chronic skin wounds in the era of personalized medicine: From bench to bedside.
Coalson E, Bishop E, Liu W, Feng Y, Spezia M, Liu B, Shen Y, Wu D, Du S, Li AJ, Ye Z, Zhao L, Cao D, Li A, Hagag O, Deng A, Liu W, Li M, Haydon RC, Shi L, Athiviraham A, Lee MJ, Wolf JM, Ameer GA, He TC, Reid RR. Stem cell therapy for chronic skin wounds in the era of personalized medicine: From bench to bedside. Genes Dis. 2019 Dec; 6(4):342-358.
PMID: 31832514

Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation, angiogenesis, tumor growth and metabolism.
Liu W, Deng Z, Zeng Z, Fan J, Feng Y, Wang X, Cao D, Zhang B, Yang L, Liu B, Pakvasa M, Wagstaff W, Wu X, Luo H, Zhang J, Zhang M, He F, Mao Y, Ding H, Zhang Y, Niu C, Haydon RC, Luu HH, Wolf JM, Lee MJ, Huang W, He TC, Zou Y. Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation, angiogenesis, tumor growth and metabolism. Genes Dis. 2020 Jun; 7(2):235-244.
PMID: 32215293

Developing a Versatile Shotgun Cloning Strategy for Single-Vector-Based Multiplex Expression of Short Interfering RNAs (siRNAs) in Mammalian Cells.
Wang X, Yuan C, Huang B, Fan J, Feng Y, Li AJ, Zhang B, Lei Y, Ye Z, Zhao L, Cao D, Yang L, Wu D, Chen X, Liu B, Wagstaff W, He F, Wu X, Luo H, Zhang J, Zhang M, Haydon RC, Luu HH, Lee MJ, Moriatis Wolf J, Huang A, He TC, Zeng Z. Developing a Versatile Shotgun Cloning Strategy for Single-Vector-Based Multiplex Expression of Short Interfering RNAs (siRNAs) in Mammalian Cells. ACS Synth Biol. 2019 09 20; 8(9):2092-2105.
PMID: 31465214

The wonders of BMP9: From mesenchymal stem cell differentiation, angiogenesis, neurogenesis, tumorigenesis, and metabolism to regenerative medicine.
Mostafa S, Pakvasa M, Coalson E, Zhu A, Alverdy A, Castillo H, Fan J, Li A, Feng Y, Wu D, Bishop E, Du S, Spezia M, Li A, Hagag O, Deng A, Liu W, Li M, Ho SS, Athiviraham A, Lee MJ, Wolf JM, Ameer GA, Luu HH, Haydon RC, Strelzow J, Hynes K, He TC, Reid RR. The wonders of BMP9: From mesenchymal stem cell differentiation, angiogenesis, neurogenesis, tumorigenesis, and metabolism to regenerative medicine. Genes Dis. 2019 Sep; 6(3):201-223.
PMID: 32042861

A simplified system for the effective expression and delivery of functional mature microRNAs in mammalian cells.
Fan J, Feng Y, Zhang R, Zhang W, Shu Y, Zeng Z, Huang S, Zhang L, Huang B, Wu D, Zhang B, Wang X, Lei Y, Ye Z, Zhao L, Cao D, Yang L, Chen X, Liu B, Wagstaff W, He F, Wu X, Zhang J, Moriatis Wolf J, Lee MJ, Haydon RC, Luu HH, Huang A, He TC, Yan S. A simplified system for the effective expression and delivery of functional mature microRNAs in mammalian cells. Cancer Gene Ther. 2020 06; 27(6):424-437.
PMID: 31222181

Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins (BMPs) in lineage commitment and differentiation of mesenchymal stem cells (MSCs).
Zhang L, Luo Q, Shu Y, Zeng Z, Huang B, Feng Y, Zhang B, Wang X, Lei Y, Ye Z, Zhao L, Cao D, Yang L, Chen X, Liu B, Wagstaff W, Reid RR, Luu HH, Haydon RC, Lee MJ, Wolf JM, Fu Z, He TC, Kang Q. Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins (BMPs) in lineage commitment and differentiation of mesenchymal stem cells (MSCs). Genes Dis. 2019 Sep; 6(3):258-275.
PMID: 32042865

Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway.
Wang X, Wu X, Zhang Z, Ma C, Wu T, Tang S, Zeng Z, Huang S, Gong C, Yuan C, Zhang L, Feng Y, Huang B, Liu W, Zhang B, Shen Y, Luo W, Wang X, Liu B, Lei Y, Ye Z, Zhao L, Cao D, Yang L, Chen X, Haydon RC, Luu HH, Peng B, Liu X, He TC. Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway. Sci Rep. 2018 12 17; 8(1):17914.
PMID: 30559409

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Orlov Visiting Professor in Orthopaedic Oncology
Loyola University of Chicago
2018

Senior Faculty Scholar
Bucksbaum Institute for Clinical Excellence
2017

Gerald S. Laros Resident Teaching Award
2011

Keynote Speaker
Pritzker School of Medicine White Coat Ceremony
2010

American-British-Canadian Traveling Fellowship, AOA
2009

Induction into ??? (Beta Chapter) as Faculty member by Pritzker School of Medicine
2008

Gerald S. Laros Resident Teaching Award
2007

Orthopaedic Research Society Career Development Award
2006

Kappa Delta Ann Doner Vaughan Award, Co-Recipient, AAOS/ORS
2006

Marshall R. Urist Young Investigator Award, Association of Bone & Joint Surgeons
2006

John J. Fahey, MD Memorial North American Traveling Fellowship, AOA
2005

K08 Mentored Clinical Scientist Development Award, NIH-NIAMS
2004 - 2009

Thomas M. Coffman OREF Career Development Award
2003 - 2005

Best Poster Award: Charles Huggins Conference: “Upregulation Of cKit In Giant Cell Tumor of Bone: Po
2002

Howard Schneider Award for Best Manuscript at the OREF Midwest Conference
2000