Rex Haydon, MD, PhD, focuses on the comprehensive treatment of malignant and benign tumors in bone or soft tissue. He specializes in the surgical care of bone and soft tissue tumors, including limb-salvage and reconstructive surgery of the upper and lower extremities. Dr. Haydon works with an integrated team of specialists to ensure that patients have access to the most innovative and effective treatment options available.
Also a skilled physician scientist, his research focuses on advancing the treatment of musculoskeletal tumors. Dr. Haydon has a particular interest in the underlying causes of musculoskeletal neoplasms. Author of more than 25 articles and book chapters, he has accepted career development awards from both the Orthopaedic Research and Education Foundation and the National Institutes of Health. Additionally, Dr. Haydon's research has been supported by the Musculoskeletal Tumor Foundation.
The University of Chicago
Chicago, Illinois
Orthopaedic Fellowship - Oncology
2003The University of Chicago
Chicago, Illinois
Orthopaedic Fellowship - Research
2002The University of Chicago
Chicago, Illinois
Resident - Orthopaedic Surgery
2001The University of Chicago
Chicago, Illinois
Ph.D - Anthropology
1996The University of Chicago
Chicago, Illinois
M.A. - MAPSS (Social Sciences),
1993The University of Chicago
Chicago, Illinois
B.A. - Anthropology
1988Identifying consensus and areas for future research in chondrosarcoma : a report from the Birmingham Orthopaedic Oncology Meeting.
Identifying consensus and areas for future research in chondrosarcoma : a report from the Birmingham Orthopaedic Oncology Meeting. Bone Joint J. 2025 Feb 01; 107-B(2):246-252.
PMID: 39889743Effective Bone Tissue Fabrication Using 3D-Printed Citrate-Based Nanocomposite Scaffolds Laden with BMP9-Stimulated Human Urine Stem Cells.
Effective Bone Tissue Fabrication Using 3D-Printed Citrate-Based Nanocomposite Scaffolds Laden with BMP9-Stimulated Human Urine Stem Cells. ACS Appl Mater Interfaces. 2025 Jan 08; 17(1):197-210.
PMID: 39718997Surgeon perspectives on a virtual reality platform for preoperative planning in complex bone sarcomas.
Surgeon perspectives on a virtual reality platform for preoperative planning in complex bone sarcomas. J Orthop. 2025 Apr; 62:43-48.
PMID: 39507951A simplified noncryogenic strategy to transport mesenchymal stem cells: Potential applications in cell therapy and regenerative medicine.
A simplified noncryogenic strategy to transport mesenchymal stem cells: Potential applications in cell therapy and regenerative medicine. Genes Dis. 2024 May; 11(3):101073.
PMID: 38274386The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities.
The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities. Genes Dis. 2024 May; 11(3):101026.
PMID: 38292186Correction: BMP9-regulated angiogenic signaling plays an important role in the osteogenic differentiation of mesenchymal progenitor cells.
Correction: BMP9-regulated angiogenic signaling plays an important role in the osteogenic differentiation of mesenchymal progenitor cells. J Cell Sci. 2023 Jun 01; 136(11).
PMID: 37272422Bone Morphogenic Protein 9 (BMP9)/Growth Differentiation Factor 2 (GDF2) modulates mouse adult hippocampal neurogenesis by regulating the survival of early neural progenitors.
Bone Morphogenic Protein 9 (BMP9)/Growth Differentiation Factor 2 (GDF2) modulates mouse adult hippocampal neurogenesis by regulating the survival of early neural progenitors. Genes Dis. 2023 Jul; 10(4):1175-1179.
PMID: 37397531Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk.
Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk. Genes Dis. 2024 Jan; 11(1):103-134.
PMID: 37588235Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases.
Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases. Genes Dis. 2023 Jul; 10(4):1351-1366.
PMID: 37397543Corrigendum to "Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference" [Genes & Diseases 5(2018):172-184].
View All Publications
Corrigendum to "Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference" [Genes & Diseases 5(2018):172-184]. Genes Dis. 2023 Mar; 10(2):632-637.
PMID: 37223525Orlov Visiting Professor in Orthopaedic Oncology
Loyola University of Chicago
2018Senior Faculty Scholar
Bucksbaum Institute for Clinical Excellence
2017Gerald S. Laros Resident Teaching Award
2011Keynote Speaker
Pritzker School of Medicine White Coat Ceremony
2010American-British-Canadian Traveling Fellowship, AOA
2009Induction into ??? (Beta Chapter) as Faculty member by Pritzker School of Medicine
2008Gerald S. Laros Resident Teaching Award
2007Orthopaedic Research Society Career Development Award
2006Kappa Delta Ann Doner Vaughan Award, Co-Recipient, AAOS/ORS
2006Marshall R. Urist Young Investigator Award, Association of Bone & Joint Surgeons
2006John J. Fahey, MD Memorial North American Traveling Fellowship, AOA
2005K08 Mentored Clinical Scientist Development Award, NIH-NIAMS
2004 - 2009Thomas M. Coffman OREF Career Development Award
2003 - 2005Best Poster Award: Charles Huggins Conference: “Upregulation Of cKit In Giant Cell Tumor of Bone: Po
2002Howard Schneider Award for Best Manuscript at the OREF Midwest Conference
2000