Lewis Shi, MD

Lewis Shi, MD, is an orthopaedic surgeon who specializes in shoulder and elbow injuries. He maximizes patients' non-operative management prior to considering surgery. If necessary, he offers minimally invasive (arthroscopic) and open procedures that are appropriate for the patient's disorders.



Dr. Shi's research focuses on the molecular basis of rotator cuff tear and biomechanics of shoulder arthritis. He also is part of several national and international multi-center studies to improve diagnostic and treatment protocols of shoulder injuries. Dr. Shi has published more than 55 peer-reviewed scientific articles and 10 book chapters.



In addition to his clinical and research work, Dr. Shi teaches medical students, residents and fellows. He has won numerous teaching awards and values his role as an educator secondary only to his role as the patient's advocate.

Harvard Shoulder and Elbow Fellowship
Boston, MA
- Shoulder/Elbow surgery
2012

Harvard Combined Orthopaedic Surgery Residency Program
Boston, MA
- Orthopaedic surgery
2011

Harvard Medical School
Boston, MA
MD
2006

Harvard College
Cambridge, MA
AB
2000

Establishment and characterization of a rat model of scalp-cranial composite defect for multilayered tissue engineering.
Establishment and characterization of a rat model of scalp-cranial composite defect for multilayered tissue engineering. Res Sq. 2024 Jul 23.
PMID: 39108474

GAPDH suppresses adenovirus-induced oxidative stress and enables a superfast production of recombinant adenovirus.
GAPDH suppresses adenovirus-induced oxidative stress and enables a superfast production of recombinant adenovirus. Genes Dis. 2024 Nov; 11(6):101344.
PMID: 39188753

Active biointegrated living electronics for managing inflammation.
Active biointegrated living electronics for managing inflammation. Science. 2024 May 31; 384(6699):1023-1030.
PMID: 38815037

HIF1a-glycolysis engages activation-induced cell death to drive IFN-? induction in hypoxic T cells.
HIF1a-glycolysis engages activation-induced cell death to drive IFN-? induction in hypoxic T cells. Res Sq. 2024 Jan 12.
PMID: 38260594

In Vivo Analysis of Acromioclavicular Kinematics and Distance During Multiplanar Humeral Elevation.
In Vivo Analysis of Acromioclavicular Kinematics and Distance During Multiplanar Humeral Elevation. Am J Sports Med. 2024 02; 52(2):474-484.
PMID: 38197156

Adipose-derived mesenchymal stem cells (MSCs) are a superior cell source for bone tissue engineering.
Adipose-derived mesenchymal stem cells (MSCs) are a superior cell source for bone tissue engineering. Bioact Mater. 2024 Apr; 34:51-63.
PMID: 38186960

Optimal Treatment of Proximal Humeral Fractures in the Elderly: Risks and Management Challenges.
Optimal Treatment of Proximal Humeral Fractures in the Elderly: Risks and Management Challenges. Orthop Res Rev. 2023; 15:129-137.
PMID: 37396822

Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk.
Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk. Genes Dis. 2024 Jan; 11(1):103-134.
PMID: 37588235

Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases.
Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases. Genes Dis. 2023 Jul; 10(4):1351-1366.
PMID: 37397543

The relationship between preoperative opioid use and adverse events following total shoulder arthroplasty.
The relationship between preoperative opioid use and adverse events following total shoulder arthroplasty. Shoulder Elbow. 2023 Dec; 15(6):653-657.
PMID: 37981971

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NIH Loan Repayment Program award
2013

Gold Medal presentation. American Roentgen Ray Society Annual Meeting.
2012

AAOS Clinical Scientist Development Program (CSDP) participant
2009

Paul Dudley White Fellowship for International Research
Harvard Medical School
2001

Community Service Award
Harvard Medical School
2001

Magna Cum Laude with Highest Honors
Harvard College
2000

Phi Beta Kappa
Harvard College
1999

Derek Bok Award for Distinguished Teaching
1999 - 2000