Kelly K. Hynes, MD

  • Assistant Professor of Orthopedic Surgery and Rehabilitation Medicine
  • Clinical Interests: Ankle Arthroscopy, Foot and Ankle Arthritis, Foot and Ankle Trauma, Forefoot Reconstruction, Orthopaedic foot and ankle care
  • Research and Scholarly Interests: Ankle, Ankle Injury, Ankle Replacement, Total, Arthritis, Arthroscopic Surgery, Arthroscopy, Bunion, Foot, Foot Injuries, Foot, Flat, Fracture, Bone
  • Websites: Research Network Profile
  • Contact: khynes@bsd.uchicago.edu

Dr. Kelly Hynes specializes in the diagnosis and treatment of all Orthopaedic foot and ankle conditions, including trauma, sports injuries (including foot and ankle arthroscopy), forefoot deformity (such as bunions) and degenerative disease (including total ankle arthroplasty). She provides skilled, compassionate care to treat pain and restore function for a broad range of common and complex foot and ankle disorders.



Dr. Hynes has an interest in health care delivery and biomedical informatics. She is the Ambulatory Medical Director for the department of Orthopaedic Surgery and Rehabilitation Medicine as well as a Medical Director of Informatics for UChicago Medicine. She is also committed to the education of future generations of Orthopaedic surgeons and teaches at regional and international courses.

University of British Columbia
Fellowship

University of Ottawa
Residency

Memorial University of Newfoundland and Labrador
MD

Diabetic Kidney Disease is Associated with Increased Complications Following Operative Management of Ankle Fractures.
Polachek WS, Baker HP, Dahm JS, Strelzow J, Hynes KK. Diabetic Kidney Disease is Associated with Increased Complications Following Operative Management of Ankle Fractures. Foot Ankle Orthop. 2022 Jan; 7(1):2473011421S00399.
PMID: 35097886

Preoperative Opioid Prescription is a Risk Factor for Extended Opioid Filling After Ankle Arthroscopy.
Polachek WS, Lee C, Scott BL, Hynes KK. Preoperative Opioid Prescription is a Risk Factor for Extended Opioid Filling After Ankle Arthroscopy. Foot Ankle Orthop. 2022 Jan; 7(1):2473011421S00400.
PMID: 35097887

A functional autophagy pathway is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs).
Zhao X, Huang B, Wang H, Ni N, He F, Liu Q, Shi D, Chen C, Zhao P, Wang X, Wagstaff W, Pakvasa M, Tucker AB, Lee MJ, Wolf JM, Reid RR, Hynes K, Strelzow J, Ho SH, Yu T, Yang J, Shen L, He TC, Zhang Y. A functional autophagy pathway is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs). Am J Transl Res. 2021; 13(5):4233-4250.
PMID: 34150011

Applications of Biocompatible Scaffold Materials in Stem Cell-Based Cartilage Tissue Engineering.
Zhao X, Hu DA, Wu D, He F, Wang H, Huang L, Shi D, Liu Q, Ni N, Pakvasa M, Zhang Y, Fu K, Qin KH, Li AJ, Hagag O, Wang EJ, Sabharwal M, Wagstaff W, Reid RR, Lee MJ, Wolf JM, El Dafrawy M, Hynes K, Strelzow J, Ho SH, He TC, Athiviraham A. Applications of Biocompatible Scaffold Materials in Stem Cell-Based Cartilage Tissue Engineering. Front Bioeng Biotechnol. 2021; 9:603444.
PMID: 33842441

Stem Cell-Friendly Scaffold Biomaterials: Applications for Bone Tissue Engineering and Regenerative Medicine.
Zhang Y, Wu D, Zhao X, Pakvasa M, Tucker AB, Luo H, Qin KH, Hu DA, Wang EJ, Li AJ, Zhang M, Mao Y, Sabharwal M, He F, Niu C, Wang H, Huang L, Shi D, Liu Q, Ni N, Fu K, Chen C, Wagstaff W, Reid RR, Athiviraham A, Ho S, Lee MJ, Hynes K, Strelzow J, He TC, El Dafrawy M. Stem Cell-Friendly Scaffold Biomaterials: Applications for Bone Tissue Engineering and Regenerative Medicine. Front Bioeng Biotechnol. 2020; 8:598607.
PMID: 33381499

FAMSi: A Synthetic Biology Approach to the Fast Assembly of Multiplex siRNAs for Silencing Gene Expression in Mammalian Cells.
He F, Ni N, Zeng Z, Wu D, Feng Y, Li AJ, Luu B, Li AF, Qin K, Wang E, Wang X, Wu X, Luo H, Zhang J, Zhang M, Mao Y, Pakvasa M, Wagstaff W, Zhang Y, Niu C, Wang H, Huang L, Shi D, Liu Q, Zhao X, Fu K, Reid RR, Wolf JM, Lee MJ, Hynes K, Strelzow J, El Dafrawy M, Gan H, He TC, Fan J. FAMSi: A Synthetic Biology Approach to the Fast Assembly of Multiplex siRNAs for Silencing Gene Expression in Mammalian Cells. Mol Ther Nucleic Acids. 2020 Dec 04; 22:885-899.
PMID: 33230483

The new 'normal': Rapid adoption of telemedicine in orthopaedics during the COVID-19 pandemic.
Rizzi AM, Polachek WS, Dulas M, Strelzow JA, Hynes KK. The new 'normal': Rapid adoption of telemedicine in orthopaedics during the COVID-19 pandemic. Injury. 2020 Dec; 51(12):2816-2821.
PMID: 32951916

Development of a simplified and inexpensive RNA depletion method for plasmid DNA purification using size selection magnetic beads (SSMBs).
Wang X, Zhao L, Wu X, Luo H, Wu D, Zhang M, Zhang J, Pakvasa M, Wagstaff W, He F, Mao Y, Zhang Y, Niu C, Wu M, Zhao X, Wang H, Huang L, Shi D, Liu Q, Ni N, Fu K, Hynes K, Strelzow J, El Dafrawy M, He TC, Qi H, Zeng Z. Development of a simplified and inexpensive RNA depletion method for plasmid DNA purification using size selection magnetic beads (SSMBs). Genes Dis. 2021 May; 8(3):298-306.
PMID: 33997177

Notch signaling: Its essential roles in bone and craniofacial development.
Pakvasa M, Haravu P, Boachie-Mensah M, Jones A, Coalson E, Liao J, Zeng Z, Wu D, Qin K, Wu X, Luo H, Zhang J, Zhang M, He F, Mao Y, Zhang Y, Niu C, Wu M, Zhao X, Wang H, Huang L, Shi D, Liu Q, Ni N, Fu K, Lee MJ, Wolf JM, Athiviraham A, Ho SS, He TC, Hynes K, Strelzow J, El Dafrawy M, Reid RR. Notch signaling: Its essential roles in bone and craniofacial development. Genes Dis. 2021 Jan; 8(1):8-24.
PMID: 33569510

Leptin Potentiates BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells Through the Activation of JAK/STAT Signaling.
Zhang B, Yang L, Zeng Z, Feng Y, Wang X, Wu X, Luo H, Zhang J, Zhang M, Pakvasa M, Wagstaff W, He F, Mao Y, Qin K, Ding H, Zhang Y, Niu C, Wu M, Zhao X, Wang H, Huang L, Shi D, Liu Q, Ni N, Fu K, Athiviraham A, Moriatis Wolf J, Lee MJ, Hynes K, Strelzow J, El Dafrawy M, Xia Y, He TC. Leptin Potentiates BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells Through the Activation of JAK/STAT Signaling. Stem Cells Dev. 2020 04 15; 29(8):498-510.
PMID: 32041483

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